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The Industry of Genetic Engineering

Shi Yuanchun

Strategic Study of CAE 2000, Volume 2, Issue 7,   Pages 34-38

Abstract: The author holds GMO food must be put in order by both science and relevant regulations, after reviewedthe background and new trends of present GMO debate.The current debate has focused on the public acceptability, trade benefit and relevant policy on GMOGMO food will only be interrupted for the time being, and will have another development tide under the

Keywords： genetic engineering     industry     gene modified organisms (GMO)     countermeasure    

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Regulatory issues for genetically modified animals

Perry Bradbury HACKETT

Frontiers of Agricultural Science and Engineering 2020, Volume 7, Issue 2,   Pages 188-203 doi: 10.15302/J-FASE-2019307

Abstract: However, governments worldwide have been exceedingly reluctant to support the introduction of genetically modifiedGenome engineers write genetic algorithms that drive the traits in biological organisms.

Keywords： algorithms     editing     FDA     GMO     recombinant DNA     USDA    

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Developments in genetic modification of cattle and implications for regulation, safety and traceability

Jan Pieter VAN DER BERG, Gijs A. KLETER, Evy BATTAGLIA, Martien A. M. GROENEN, Esther J. KOK

Frontiers of Agricultural Science and Engineering 2020, Volume 7, Issue 2,   Pages 136-147 doi: 10.15302/J-FASE-2019306

Abstract:

Genetic modification techniques, in particular novel gene editing technologies, hold the yet unfulfilledGene editing technologies allow for the directed alteration of specific traits and thereby have the potential

Keywords： cattle     food safety     gene editing     genetic modification     GMO detection     regulation    

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Isolation and application of predatory

Ran Yu, Shiwen Zhang, Zhoukai Chen, Chuanyang Li

Frontiers of Environmental Science & Engineering 2017, Volume 11, Issue 1, doi: 10.1007/s11783-017-0900-3

Abstract: -and-like organisms (BALOs) are a group of ubiquitous and obligate predatory bacteria and commonly used

Keywords： Bdellovibrio-and-like organisms (BALOs)     Biolysis     Activated sludge     Dewaterability     Predation    

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Study on Family Collection, Gene Mapping, Gene Identification and Gene Function of Human Genetic Diseases

Xia Jiahui

Strategic Study of CAE 2000, Volume 2, Issue 11,   Pages 1-11

Abstract:

In this paper, the study on family collection, gene mapping, gene identification and gene functiont (1; 3) (q44; p11) associated with nasopharyngeal cancer was found in 1975 at first, and human TDF geneIn 1998, GJB3, a human genetic neurological deafness gene, was identified using a novel strategy of “Gene Family-Candidate Disease Gene Cloning”，and the paper was published in Nature Geneticswas also cloned from gene function study.

Keywords： genetic disease     gene mapping and cloning     gene familiy-candidate disease gene cloning     genome wide scan     gene function study    

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Tuned reactive power dispatch through modified differential evolution technique

S. BISWAS (RAHA), N. CHAKRABORTY

Frontiers in Energy 2012, Volume 6, Issue 2,   Pages 138-147 doi: 10.1007/s11708-012-0188-8

Abstract: This paper explores the capability of modified differential evolution (MDE) technique for solving the

Keywords： reactive power dispatch (RPD)     modified differential evolution (MDE)     differential evolution algorithm    

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Approaching the binding between Cu(II) and aerobic granules by a modified titration and µ-XRF

Hongwei LUO,Longfei WANG,Zhonghua TONG,Hanqing YU,Guoping SHENG

Frontiers of Environmental Science & Engineering 2016, Volume 10, Issue 2,   Pages 362-367 doi: 10.1007/s11783-015-0803-0

Abstract: In this study, a modified titration method with a dynamic mode was developed to investigate the binding

Keywords： aerobic granules     Cu(II)     modified titration     µ-XRF analysis    

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Molecular engineering of dendrimer nanovectors for siRNA delivery and gene silencing

Yu Cao, Xiaoxuan Liu, Ling Peng

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 4,   Pages 663-675 doi: 10.1007/s11705-017-1623-5

Abstract: Small interfering RNA (siRNA) therapeutics hold great promise to treat a variety of diseases, as long as they can be delivered safely and effectively into cells. Dendrimers are appealing vectors for siRNA delivery by virtue of their well-defined molecular architecture and multivalent cooperativity. However, the clinical translation of RNA therapeutics mediated by dendrimer delivery is hampered by the lack of dendrimers that are of high quality to meet good manufacturing practice standard. In this context, we have developed small amphiphilic dendrimers that self-assemble into supramolecular structures, which mimic high-generation dendrimers synthesized with covalent construction, yet are easy to produce in large amount and superior quality. Indeed, the concept of supramolecular dendrimers has proved to be very promising, and has opened up a new avenue for dendrimer-mediated siRNA delivery. A series of self-assembling supramolecular dendrimers have consequently been established, some of them out-performing the currently available nonviral vectors in delivering siRNA to various cell types and , including human primary cells and stem cells. This short review presents a brief introduction to RNAi therapeutics, the obstacles to their delivery and the advantages of dendrimer delivery vectors as well as our bio-inspired structurally flexible dendrimers for siRNA delivery. We then highlight our efforts in creating self-assembling amphiphilic dendrimers to construct supramolecular dendrimer nanosystems for effective siRNA delivery as well as the related structural alterations to enhance delivery efficiency. The advent of self-assembling supramolecular dendrimer nanovectors holds great promise and heralds a new era of dendrimer-mediated delivery of RNA therapeutics in biomedical applications.

Keywords： gene therapy     RNAi therapeutics     dendrimer     nanovectors     gene silencing    

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Kinetics and thermodynamics of the phosphine adsorption on the modified activated carbon

Bingnan REN

Frontiers of Chemical Science and Engineering 2011, Volume 5, Issue 2,   Pages 203-208 doi: 10.1007/s11705-010-0571-0

Abstract: The kinetics and the thermodynamics of phosphine (PH ) adsorption on the modified activated carbon have

Keywords： adsorption     PH3     activated carbon     kinetics     thermodynamics    

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excessive anaerobic reaction time on anaerobic metabolism of denitrifying polyphosphate- accumulating organisms

Gang GUO, Yayi WANG, Chong WANG, Hong WANG, Mianli PAN, Shaowei CHEN

Frontiers of Environmental Science & Engineering 2013, Volume 7, Issue 4,   Pages 616-624 doi: 10.1007/s11783-013-0505-4

Abstract: The short-term effect of anaerobic reaction time (AnRT) (i.e., 90, 120 and 150 min) on the denitrifying phosphorus (P) removal performance and N O production was examined using a denitrifying enhanced biologic phosphorus removal (EBPR) sludge acclimatized with mixed acetate (HAc) and propionate (Pro) (in the molar ratio 3∶1) as carbon sources. The results showed that when the AnRT was prolonged from 90 to 150 min, the anaerobic polyhydroxyalkanoate (PHA) synthesis was decreased by 15.3%. Moreover, the ineffective PHA consumption occurred in anaerobic phases and contributed to an increased accumulation and higher free nitrous acid (FNA) concentrations (≥0.001–0.0011 mg HNO -N/L) in the subsequent anoxic phases, causing a severe inhibition on anoxic P-uptake and denitrification. Accordingly, the total nitrogen (TN) and total phosphorus (TP) removal efficiencies dropped by approximately 6.3% and 85.5%, respectively; and the ratio of anoxic N O-N production to TN removal increased by approximately 3.8%. The fluorescence in situ hybridization (FISH) analysis revealed that the sludge was mainly dominated by (62.0% (SE = 1.5%)). In conclusion, the short-term excessive anaerobic reaction time negatively impacted denitrifying P removal performance and stimulated more N O production, and its effect on P removal was more obvious than that on nitrogen removal.

Keywords： Denitrifying phosphorus removal     anaerobic reaction time     nitrous oxide     polyhydroxyalkanoate     free nitrous acid     fluorescence in-situ hybridization    

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Removing phosphorus from aqueous solutions by using iron-modified corn straw biochar

Fenglin LIU,Jiane ZUO,Tong CHI,Pei WANG,Bo YANG

Frontiers of Environmental Science & Engineering 2015, Volume 9, Issue 6,   Pages 1066-1075 doi: 10.1007/s11783-015-0769-y

Abstract: Iron-modified corn straw biochar was used as an adsorbent to remove phosphorus from agricultural runoffmg·L were filtered at a hydraulic retention time of 2 h through a filtration column packed with the modifiedThe isotherms of the phosphorus adsorption by the modified biochar fitted the Freundlich equation betterThe results also showed that new iron oxides were formed on the surface of the modified biochar afterAside from removing phosphorus, adding the modified biochar into soil also improved soil productivity

Keywords： iron-modified biochar     phosphorus removal     agricultural waste     agricultural runoff    

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The antibiotic resistome: gene flow in environments, animals and human beings

Yongfei Hu, George F. Gao, Baoli Zhu

Frontiers of Medicine 2017, Volume 11, Issue 2,   Pages 161-168 doi: 10.1007/s11684-017-0531-x

Abstract: We propose that the resistance gene flow in nature is “from the natural environments” andand animals, as intermediate recipients and disseminators, contribute greatly to such a resistance gene

Keywords： antibiotic resistance     resistome     microbiome     gene flow    

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Reflections on the system of evaluation of gene-edited livestock

Ziyao FAN, Tianwen WU, Kui WU, Yulian MU, Kui LI

Frontiers of Agricultural Science and Engineering 2020, Volume 7, Issue 2,   Pages 211-217 doi: 10.15302/J-FASE-2019303

Abstract: functions regarding economic traits, and new materials for livestock breeding have been obtained through geneEvaluation is the most important component of the regulation of gene-edited livestock and is a crucialguarantee of public safety before the marketing of gene-edited animal products.Here, the system of evaluation of gene-edited livestock is discussed in terms of public safety and production

Keywords： evaluation     gene editing     livestock     performance     safety    

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Immobilization of penicillin G acylase onto amino-modified silica hydrogel

Weibing Dong, Huining HE, Junbo Gong, Victor C. YANG,

Frontiers of Chemical Science and Engineering 2010, Volume 4, Issue 1,   Pages 87-90 doi: 10.1007/s11705-009-0298-y

Abstract: Amino-modified silica hydrogel (N-MSHG) was prepared by a simple sol-gel processing via the co-condensationThe results showed that the amino-modified gel was a mesoporous material with an average pore size of

Keywords： gravimetric     amino-modified     efficient     Amino-modified     amoxicillin    

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Distinct gene expression pattern of mutations coordinated by target repression and promoter hypermethylation

Frontiers of Medicine 2022, Volume 16, Issue 4,   Pages 627-636 doi: 10.1007/s11684-020-0815-4

Abstract: Then, based on RNA-seq data from The Cancer Genome Atlas AML cohort, we developed a 300-gene signatureThis study revealed the distinct gene expression pattern of RUNX1 mutations and the underlying

Keywords： RUNX1     gene mutation     acute myeloid leukemia     transcriptional repression     DNA methylation    

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Title Author Date Type Operation

The Industry of Genetic Engineering

Shi Yuanchun

Journal Article

Regulatory issues for genetically modified animals

Perry Bradbury HACKETT

Journal Article

Developments in genetic modification of cattle and implications for regulation, safety and traceability

Jan Pieter VAN DER BERG, Gijs A. KLETER, Evy BATTAGLIA, Martien A. M. GROENEN, Esther J. KOK

Journal Article

Isolation and application of predatory

Ran Yu, Shiwen Zhang, Zhoukai Chen, Chuanyang Li

Journal Article

Study on Family Collection, Gene Mapping, Gene Identification and Gene Function of Human Genetic Diseases

Xia Jiahui

Journal Article

Tuned reactive power dispatch through modified differential evolution technique

S. BISWAS (RAHA), N. CHAKRABORTY

Journal Article

Approaching the binding between Cu(II) and aerobic granules by a modified titration and µ-XRF

Hongwei LUO,Longfei WANG,Zhonghua TONG,Hanqing YU,Guoping SHENG

Journal Article

Molecular engineering of dendrimer nanovectors for siRNA delivery and gene silencing

Yu Cao, Xiaoxuan Liu, Ling Peng

Journal Article

Kinetics and thermodynamics of the phosphine adsorption on the modified activated carbon

Bingnan REN

Journal Article

excessive anaerobic reaction time on anaerobic metabolism of denitrifying polyphosphate- accumulating organisms

Gang GUO, Yayi WANG, Chong WANG, Hong WANG, Mianli PAN, Shaowei CHEN

Journal Article

Removing phosphorus from aqueous solutions by using iron-modified corn straw biochar

Fenglin LIU,Jiane ZUO,Tong CHI,Pei WANG,Bo YANG

Journal Article

The antibiotic resistome: gene flow in environments, animals and human beings

Yongfei Hu, George F. Gao, Baoli Zhu

Journal Article

Reflections on the system of evaluation of gene-edited livestock

Ziyao FAN, Tianwen WU, Kui WU, Yulian MU, Kui LI

Journal Article

Immobilization of penicillin G acylase onto amino-modified silica hydrogel

Weibing Dong, Huining HE, Junbo Gong, Victor C. YANG,

Journal Article

Distinct gene expression pattern of mutations coordinated by target repression and promoter hypermethylation

Journal Article